Repeated high-dose inhalation allergen challenge in asthma
نویسندگان
چکیده
منابع مشابه
Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge
BACKGROUND Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma. However, clinical symptoms are less likely to be induced. Therefore, we designed a protocol for repetitive high-dose bronchial allergen challenges to generate clinical symptoms and airway inflammation. METHO...
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Airway inflammation is thought to play an important role in the pathogenesis ofasthma. We have used in situ hybridization and an immunoassay to determine whether granulocyte macrophage colony-stimulating factor (GM-CSF) (a cytokine capable of eosinophil activation) is present in the airway of asthmatics (n = 6) who have 37.0±15.1% airway eosinophilia after endobronchial allergen challenge. Leve...
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Repeated low-dose allergen inhalation challenge mimics natural allergen exposure, providing a model for early mechanisms in the triggering of asthma. The current authors performed a controlled study to evaluate the time course of changes in exhaled nitric oxide fraction (F(e,NO)) and urinary biomarkers of airway inflammation. Eight subjects with mild allergic asthma completed two 7-day repeated...
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Until the late 1960's there was a remarkable lack of information on the consequences of asthma on arterial oxygenation [1, 2). Since then, it has been known that arterial blood gas abnormalities can range from overt hypoxaemia, usually associated with hypocapnia and respiratory alkalosis, as shown in acute severe asthma, to mild increases in the alveolar-arterial 0 2 tension difference (AaPo,) ...
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ژورنال
عنوان ژورنال: The Clinical Respiratory Journal
سال: 2010
ISSN: 1752-6981
DOI: 10.1111/j.1752-699x.2010.00212.x